The actions of the fantastic roguelike REMEDIUM Sentinels take the user to an alternative future when humanity is faced with a powerful scourge — a deadly disease called the Gray Plague. The attack did not give the states a single chance to resist lightning-fast spread and a high degree of infection led to irreversible consequences for civilization. A healthy body, soon after the pathogen got inside, turned into a body disfigured by mutations and gene changes with uncontrolled aggression. The protagonist of REMEDIUM Sentinels is a special soldier with the nickname Sentinel. The advanced technology of closed settlements that continue to resist has made it possible to modify the soldiers and turn them into versatile warriors with increased performance and resilience in battle.