GUNTOUCHABLES puts 1 to 4 players in the role of skilled survivors in a post-apocalyptic environment. The main objective is to reclaim land from hordes of hostile, constantly evolving mutants. These creatures constantly invent new methods of eliminating heroes, bringing fresh threats with each battle. The gameplay is tied to the confrontation with this dynamically changing enemy force. Progression through the story is tied to completing missions, for which UpCrates are awarded with currency and perks to increase the chances of survival.