BioMenace Remastered is a reimagining of the classic two-dimensional platformer, the gameplay of which is based on dynamic shootouts and the exploration of multi-level locations. The storyline unfolds in the metropolis of Metro City, which has been attacked by mutated creatures. The central figure of the story is the secret operative Snake Logan, whose reconnaissance mission fails. After the plane crash, he has to face the hordes of monsters alone and find the source of their appearance. The protagonist must stop the evil scientist Dr. Mangle, saving the survivors along the way.