Touhou Mystias Izakaya takes gamers to a fictional Japanese town called Gensoke, where the young and very charming owner of the local night izakaya lives. This term usually refers to a night drinking establishment where people gather, usually after a night shift, and drink alcoholic beverages. The protagonist is the beautiful Mistia Lorelei, who has a dream to make the entire establishment the most popular in the city. The events of game begin to take place at a moment when all the heroine’s hopes are almost destroyed. She comes under the radar of the local, very influential Yakumo family, whose actions are causing the izakaya to be on the verge of closure.