High Spirits is a potion-based RPG where players navigate a magical town, unlock lost memories, and battle powerful spirits. The title centers on Flanagan, who wakes up in the Kickin' Mule tavern with a talking staff and no memory of the previous night. Players gather ingredients, craft potions, and adapt their fighting styles by drinking these drinks. Drinking too much leads to unpredictable effects, adding a twist to the encounters.